VIPCOT™ Roundup Ready Flex™ cotton

The stacked cotton line COT102 x COT67B x 88913 was produced by cross breeding between cotton LMOs COT102, COT67B and 88913 to resist the lepidopteran pests such as the cotton bollworm (Helicoverpa zea), amongst others, as well as tolerance against the herbicide glyphosate via the introduction of the Vip3A, Cry1Ab and EPSPS genes respectively.

PV-GHGT35, pCOT-1, pNOV4641 and pNOV1914

DNA insert from COT102 vector pCOT-1:
Cotton tolerant to lepidopteran pests through introduction of the vip3A(a) gene which codes for an insecticidal protein that targets lepidopteran insect species. The aph4 gene, coding for hygromycin-B phosphotransferase (APH4) was used as a selectable marker.

DNA insert from COT67B vector pNOV4641 and pNOV1914:
Cotton resistant to lepidopteran pests through introduction of the cry1Ab gene, in the pNOV4641 vector, which codes for the Cry1Ab insecticidal protein that targets lepidopteran insect species. The pNOV1914 vector contained a selection marker and was selected against using traditional plant breeding techniques.

DNA insert from 88913 vector PV-GHGT35:
This genetically engineered cotton contains a novel form of the plant enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) that allows MON 88913 to survive otherwise lethal applications of glyphosate.

For additional information on this LMO, please refer to the records of the parental LMOs.