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Gene and DNA Sequence
Record information and status
Record ID
115112
Status
Published
Date of creation
2019-08-16 20:40 UTC (austein.mcloughlin@cbd.int)
Date of publication
2019-08-16 20:40 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
Iron-regulated transporter 1
Alternate Genetic Element Name (synonyms)
At4g19690.2
AtIRT1
Abbreviation
IRT1
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
No
Donor organism
Donor organism
Arabidopsis thaliana - Thale cress, Mouse-ear cress, Arabidopsis, ARATH
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
IRON-REGULATED TRANSPORTER 1
Biological function
The Arabidopsis thaliana IRON-REGULATED TRANSPORTER 1 (IRT1) is a high-affinity iron (ferrous ion - Fe2+) transporter, essential for the uptake of iron from the soil into the root epidermal layer. The protein belongs to the Zrt/Irt-like protein (ZIP) family of transporters and is involved in cellular metal homeostasis. IRT1 also mediates the uptake of divalent metal ions, including heavy metals, under iron-deficient conditions. The availability of secondary metal ions (e.g. Zn, Co, Mn) control the intracellular location of the protein.

Previous overexpression experiments demonstrated increased levels of iron in transgenic rice and cassava. Loss-of-function mutations lead to lethal chlorotic phenotype.
Related trait(s) or use(s) in biotechnology
  • Changes in quality and/or metabolite content
  • Increased levels of iron

Records referencing this document (4)
IDDescription
4record(s) found
Modified Organism4 records