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Dr Alexis Henry Gaetan Goux
President of CIBio
Ceva Saúde Animal Ltda (CEVA)
Rua Manuel Joaquim Filho, 303 Pulínia - SP
Paulínia, São Paulo
The Vectormune® AI poultry vaccine is based on a Marek's Disease
virus strain FC-126 (HVT FC-126), which is a non-pathogenic
serotype of turkey herpesvirus (HVT), which is commonly used as a
vaccine strain. The recombinant, modified virus expresses the H5
subtype of the hemagglutinin (HA) protein of the Avian Influenza
virus (AIV). The vaccine is expected to confer protection to Avian
influenza, which is a major respiratory disease in poultry.
The term Recipient organism refers to an organism (either already modified or non-modified) that was subjected to genetic modification, whereas Parental organisms refers to those that were involved in cross breeding or cell fusion.
Meleagrid alphaherpesvirus 1 - Turkey herpesvirus, Meleagrid herpesvirus 1
Turkey Herpesvirus (HVT) strain FC-126
Some of these genetic elements may be present as fragments or truncated forms. Please see notes below, where applicable.
Hemagglutinin gene - Influenza A virus - Influenza, Flu, Avian flu, Human flu, Swine influenza, Equine influenza, Bird flu
Production of medical or pharmaceutical compounds (human or animal) - Vaccines
The biological agent, called rHVT / AI, contains a recombinant
turkey herpesvirus (HVT), which expresses the hemagglutinin (HA)
protein (H5 subtype) of the Avian Influenza virus (AIV). The HA
gene is under control of the Cytomegalovirus promoter and was
inserted into an intergenic non-coding region of the HVT genome.
The inserted donor DNA fragment was obtained through amplifying the
HA gene (H5 subtype) from the single-stranded RNA genome of the AIV
using polymerase reverse transcriptase (RT-PCR) chain reaction. The
AIV HA gene is expected to be expressed in several recombinants.
This gene is also used in a similar avian yaws-influenza vector
vaccine, which is licensed by the USDA.
- Production of medical or pharmaceutical compounds (human or animal)