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Gene and DNA Sequence
Record information and status
Record ID
Date of creation
2006-06-09 16:46 UTC (kirsty.mclean.consultant@cbd.int)
Date of last update
2021-02-12 16:44 UTC (austein.mcloughlin@cbd.int)
Date of publication
2021-02-12 16:44 UTC (austein.mcloughlin@cbd.int)

General information
Name of the gene or DNA sequence
5-enolpyruvylshikimate-3-phosphate synthase gene
Alternate Genetic Element Name (synonyms)
3-phosphoshikimate 1-carboxyvinyltransferase
Category of DNA sequence
  • Protein coding sequence
Is the gene / DNA sequence is a synthetic molecule?
Donor organism
Donor organism
Agrobacterium tumefaciens - Agrobacterium
Donor organism point of collection
Agrobacterium tumefaciens strain CP4
Characteristics of the protein coding sequence
Name of the protein expressed by the coding sequence
5-enolpyruvulshikimate-3-phosphate synthase
Biological function
The cp4 epsps gene was isolated from the CP4 strain of the common soil bacterium Agrobacterium tumefaciens. The enzyme encoded by the sequence is a version of EPSPS that is highly tolerant to inhibition by glyphosate and therefore leads to increased tolerance to glyphosate-containing herbicides. The following reaction is catalyzed by EPSPS:

3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate

Glyphosate specifically binds to and inactivates the enzyme EPSPS, which is part of an important plant biochemical pathway called the shikimate pathway. The shikimate pathway is involved in the biosynthesis of the aromatic amino acids tyrosine, phenylalanine and tryptophan, as well as other aromatic compounds. When plants are treated with glyphosate herbicides they cannot produce the aromatic amino acids that are essential to their survival and, therefore, die.

LMOs containing the glyphosate-tolerant epsps gene allow farmers to use glyphosate-containing herbicides for weed control, which will kill the weeds but not the LMO.
Related trait(s) or use(s) in biotechnology

Records referencing this document (2260)
2260record(s) found
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Organization15 records
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